The Sensational She-Hulk: Animated Series is an upcoming animated series based on the Marvel Comics Character & Comic Series of the Same Name. She-Hulk will be voiced by Rosario Dawson.
- She-Hulk/Jennifer Walters (voiced by Rosario Dawson): The main protagonist. Crusading lawyer Jennifer Walters was Bruce Banner's cousin, and needed an emergency transfusion of his blood after being shot. Along with Banner's blood, Jennifer received his ability to transform into a green-skinned drop-dead gorgeous young woman with a lushly-curved yet powerfully-muscled physique with a beautiful mane of dark-green hair. She'll be wearing her purple one-piece swimsuit with a white belt, wrist bands and purple boots as her primary costume.
- Delilah Dearborn/Geiger:
- Cassandra Pike: The Main Antagonist.
- Enclave: The true main antagonists. An organization that was founded by six mysterious scientists masked in full, high-tech, body armor with different capabilities.
- Silvanus Leader/Sebastian Kane (Neil Kaplan): His suit is powered with radioactive energy gives him Super strength, Radiation Manipulation and Atomic blasts. His armor light is green
- Jupiter Leader/Vostok Shinski (Chris Cox): His armor gives him weather manipulation, allowing him to summon lighting, wind storms. His armor light is yellow
- Ceres Leader/Stella Webb (Samulee Mantano): Her bio suit is enhanced superhuman stregth and agility. Her armor light is cyan.
- Vulcan Leader/Theodore Goodrich (J.B. Blanc): His armored battle-suit is loosely based of Hulkbuster exo suit which provides him superhuman strength, with orbital lasers via satellite communication. armor light is gamboge.
- Minerva Leader/Carla Marlowe (Grey DeLisle): Her suit enables her to create hard-light illusion holograms of herself, telekinesis and psionic blasts. Her armor light is lavender
- Neptune/Anton (Liam O'Brien): His. His armor light is indigo.
- Legionnaire soldiers
- Barbaria: Mutant genetically altered clones of Bi-Beast.
- Kyklops: Giant robots produced in Vulcans division.
- Bruce Banner/Hulk (Came Clarke and Fred Tatasciore)
- Rick Jones/A-Bomb (Andrew Francis)
- Betty Ross (Tara Platt)
- American Kaiju/Todd Ziller (John DiMaggio)
- Doc Samson (Daniel Riordan)
- The Fantastic Four
- Mr Fantastic (Dee Bradley Baker)
- Invisable Woman (Nicole Sullivan)
- The Human Torch ()
- The Thing
- Peter Parker/Spider-Man
- Tony Stark/IronMan
- Guardians of Infinity
- Stella Nega (Ashleigh Bal)
- Tua Zon the Colonizer
- Pretty Persuasions
- Titania: The Arch Rival of She-Hulk
- Radioactive Man
- Half-Life (Steve Blum): This version of Half-Life looks like a bald-headed, vampire-like creature rather than the green-skinned zombie of the comics. He can absorb gamma energy to be able sustain himself.
- Lady Octopus
- Rosario Dawson - Jennifer Walters/She-Hulk
- Fred Tatasciore - The Hulk, Red Hulk
- John DiMaggio - Cain Marko/Juggernaut, Carl "Crusher" Creel/Absorbing Man, Alex O'Hirn/Rhino, Benjamin J. Grimm/The Thing, Grey Hulk, A-Bomb, Wendigo, Bi-Beast (Lower head), Zzzax, Philip Sterns/Madman
- Luke Perry - Rick Jones
- Chi McBribe - Nick Fury
- J.B. Blanc - Michael Steel/Iron Clad
- Richard Moll - Emil Blonsky/Abomination, Brian Banner/Devil Hulk
- Steven Blum - Anthony Masterson/Half-Life, James Howlett/Logan/Wolverine
- Daran Norris - Venom, John Jameson, Zzzax
- Matthew Frewer - Samuel Sterns/The Leader
- Mark Hamill - Yuri Toropov/Gargoyle, Arkaday Rosovich/Omega Red, Nightmare
- Vanessa Marshall - Betty Ross-Banner/Red She-Hulk, Ogress
- Susan Eisenberg - Thundra
- Jennifer Hale - Delilah Dearborn/Geiger
- Cam Clarke - Leonard Samson/Doc Samson, Reed Richards/Mr Fantastic, Simon Utrecht/Vector, Thor
- Adrien Pasdar - Tony Stark/Ironman
- David Kaye - J.A.R.V.I.S.
- Nolan North - Maj. Glenn Talbot, Johnny Blaze/Ghost Rider, Wade Wilson/Deadpool
- Clancy Brown - Johann Scmidt/Red Skull
- J.G. Hertzler - Tony Masters/Taskmaster
- Bumper Robinson - Samuel Wilson/Falcon
- James Arnold Taylor - James Buchanan Barnes/Winter Soldier
- Keith Ferguson - Gen. Thunderbolt Ross, James Darnell/X-Ray, Bi-Beast(Upper head)
- Danica McKellar - Susan Storm/Invisible Woman, Ann Darnell/Vapor
- Khary Payton - Gabe Jones
- Grey DeLisle - Agent Cheesecake, Louise Mason/Blonde Phantom, Jocasta, Janet Van Dyne-Pym/Wasp, Wanda Maximoff/Scarlet Witch, Abigail Brand, Pepper Potts/Rescue
- Cree Summer - Lyra, Network
- Wade Williams - Zzzax
- Vanessa Marshall - Abigail Mercy Wright/Mercy, Natasha Romonoff/Black Widow, Mary McPherran/Titana
- Dawnn Lewis - Ororo Munroe/Storm, Lucia Von Bardas
- Tasia Valenza - Jessica Drew/Spider-Woman, Greer Grant Nelson/Tigra
- Maurice LaMarche - The Mad Thinker
- James Horan - Stephen Strange/Doctor Strange, Ultron
- April Stewart - Carol Danvers/Ms Marvel
- Neil Patrick Harris - Peter Parker/Spider-Man, Peter Corbeau
- George Takei - The Mandarin, Wong
- Dorian Harewood - Col. James Rhodes/War Machine
- Leigh Allyn-Baker - Jean Grey
- Brent Spiner - Zebidiah Killgrave/Purple Man
- Gabrielle Carteris - Elektra
- Brian Bloom - Matthew Murdock/Daredevill
- Peter Lurie - Bullseye
- David Sobolov - Wilson Fisk/Kingpin
- Charlie Adler - George Tarlenton/M.O.D.O.K.
- Collette Sunderman - Casting & Voice Director
|Episode Title||Episode Plot|
|The Worst Nightmare|
|Return of the Leader|
|Hulk on a Diffrent Color|
|The Color Grey|
|Masters of Tasks|
|Revenge of the Red Skull|
|Four Plus One|
|Meet the Madman|