In this epic conclusion to this prehistoric franchise, the neanderthals returned to destroy the Isolated Island and Manny, Sid, Diego, Ellie, Shira, Granny, Crash and Eddie must stop the Humans and save their home on an epic final adventure,
July 15, 2016
- Ray Romano as Manny, a Woolly Mammoth and the "Man of Family".
- John Leguizamo as Sid, a lazy, but caring Ground Sloth.
- Denis Leary as Diego, a Smilodon, Shira's love interest and Manny's best friend.
- Seann William Scott as Crash, an opossum, Eddie's brother and close friend, and Ellie's adoptive brother.
- Josh Peck as Eddie, an opossum, Crash's brother and close friend, and Ellie's adoptive brother.
- Josh Hucterson as Roshan, Manny, Sid and Diego's old friend.
- Gary Oldman as Kal, the mean and selfish uncle of Roshan whom wants cause the Extinction.
- Wanda Sykes as Granny, Sid's 80-year-old grandmother.
- Jennifer Lopez as Shira, a Smilodon, Diego's love interest and Gutt's former mate.
- Queen Latifah as Ellie, a Woolly Mammoth who is Manny's wife and Peaches' mother.
- Josh Gad as Louis, a molehog and Peaches' best friend who has a crush on her.
- Keke Palmer as Peaches, a teenage Woolly Mammoth and Manny and Ellie's daughter.
- Chris Wedge as Scrat, a sabre-toothed squirrel.
- Tyler Perry as Griffin, a short-faced bear, who follows The Gang.
- Chris Rock as Brur, a dire wolf, who also follows The Gang.
- Leslie Mann as Sanaa, a sloth and Sid's love interest.
- Cale Blanchett as Dolores, Manny's wife before Ellie who survived, and reunited Manny.
- Nathan Gamble as Ian, Manny's son, Peaches' half-brother.
- Gerard Butler as Runar, Roshan's father only seen in flashback, he was killed by Kal because he want to stop the extinction, like his son.