- Anakaris (Jim Cummings) - Asks a riddle before battle!
- Bishamon (Keone Young)
- Demitri Maximoff (Rick D. Wasserman) - 1st main character
- Felicia (Colleen O'Shuganessy)
- Huitzil (David Lodge) - created by "The Government" to capture the old races!
- Jon Tailban (Wentworth Miller)
- Lord Raptor (Scott McNeil)
- Morrigan Aensland (Ashley Johnson)
- Pyron (Kevin Michael Richardson) - the main antagonist, and like the 1995 animated series is the brother of Terramon (Kevin Michael Richardson), Aquarias (Cindy Robinson), Zephyro (Ogie Banks)!
- Rikuo (Neil McDonough)
- Sasquatch (Frank Welker) - the comic relief with the same personality as Bigfoot from "A Goofy Movie"!
- Victor von Gerdenheim (Troy Baker)
- Donovan Bane (David Kaye)
- Hsien-Ko (Kim Mai Guest)
- B.B. Hood (Tara Strong)
- Lilith (Grey DeLisle)
- Q-Bee (Miss Kittie)
- Harry Grimorie (Jeremy Shada)
- Anita (Ariel Winter)
- Lillith (Kath Soucie)
- Jedah (Clancy Brown)
- Into the Night
- Ways of the Samurai!