Batman uncovered a secret of the Skrulls, and has caused an event known as a world collison and and has caused Trauma to the limbo, Batman must unite with Marvel characters, before the Skrulls take control of the universes.
- Hulk vs. Bane: Bane is hired by Solomon Grundy to capture the Hulk so he could battle him. Flash helps Hulk escape from Vlatava.
- Captain America vs. Deadshot: Captain America became a target of C.H.E.C.M.A.T.E. and Deadshot is the guns that is after him.
- Green Lantern vs. Thor: Loki and Sinestro make an alliance to destroy the guardians, and the Asgardians, and the Skrulls are involved.
- Batman vs. Dr. Doom: Batman heads for Latveria, and uncovers the mystery of the Fantastic Four.
- Teen Titans vs. X-Men: Magneto hires Deathstroke the Terminator, to take out Senator Kelly, and "all the ones against Mutants".
- Galactus vs. Darksied: Two Powerful warriors battle for power of the Universe.
- Dennis Quaid - Bruce Wayne/ Batman
- Manu Bennett - Commander Klrrt/ Super-Skrull
- Jeremy Irons - Slade Wilson/ Deathstroke
- Kevin Sorbo - Clarke Kent/ Superman
- Patrick Stewart - Prof. Xaviar
- Samuel. L Jackson - Nick Fury
- Jodi Benson - Starfire, Carol Ferris/Star Sapphire, Selina Kyle/Catwoman
- Jason Marsden - Peter Parker/ Spider-Man
- Neil McDonough - Tony Stark/ Iron Man
- Thomas Hayden Church - Flint Marko/ Sandman
- Bruce Greenwood - Matt Murdoch/ Daredevil
- Clancy Brown - Lex Luthor, Ben Grimm/ The Thing
- Rino Romano - Steve Rogers/ Captain America, Deadshot, Cyclops
- David Kaye - Brother Blood, Galactus
- Cheech Marin - Bane
- Fred Tatasciore - Hulk, Solomon Grundy, Mongul
- Christian Slater - Aquaman
- Mark Hamill - Dr. Victor Von Doom
- Graham McTavish - Ra's al Ghul
- Ron Perlman - Magneto
- Gary Cole - Sentator Kelly
- Steven Blum - Wolverine, Hal Jordan
- Kevin Michael Richardson - Norman Osborn/ Green Goblin, Juggernaut, Apocalypse, Killer Croc, Clayface
- Cree Summer - Cheetah
- Greg Cipes - Beastboy, Gambit
- Ashley Johnson - Rogue
- Neil Patrick Harris - Kane
- Charlie Adler -Riddler, Scarecrow